A window of understanding the Liver Growth

Three novel genes where induced (G0s2, Ccnd1 and Scd1) (and two marker genes CYP4A1 and CYP3A1) were confirmed to be up-regulated at the hours 1 and 3 after dosing with peroxisome proliferators and not 24 hours, and the G0s2 and Scd1 were specific for the ciprofibrate suggesting they were involved in a distinct PPARa pathway responsible for the hepatic DNA synthesis. The complete database of the transcriptional response provided here opens doors of opportunity for further research to identify genes responsible for the liver growth induced by peroxisome proliferators.