Interplay Between Drugs And Metabolism

Predicting the fate of a drug in a particular patient and the subsequent response is still a vision and far away from application in routine clinical practice .Drug metabolism was defined as the main process responsible for biotransformation of xenobiotics in the body to make them more water soluble and thus more readily excreted in the urine or bile. CYP450s are a major source of variability in drug metabolism. Of 57 attributive functional human CYPs only about a dozen enzymes, belonging to the CYP1, 2, and 3 families, are responsible for the biotransformation of most foreign substances including 70-80% of all drugs in clinical use. The current work was designed to pore over the effect of dexamethasone and fluconazole as CYP-450 inducer and inhibitor respectively, on the metabolism of some endogenous steroidal hormones. Furthermore, highlighting their reflection on the concerning parameters and investigating their effects on an exogenously administered steroid hormone.