Beneficial effect of Curcumin on Helicobacter pylori eradication

Introduction: Peptic ulcer disease (PUD) is the erosion in lining of stomach or duodenum. Predominantly caused by Helicobacter pylori infection in about 50% of the world’s population.which can colonize in the gastric antrum of all patients producing an extensive, noninvasive inflammatory reaction in the gastric mucosa.Methods: Fortey patients newly diagnosed endoscopically with peptic ulcer disease to be allocated into group 1 treated with standard H. pylori eradication triple therapy, and group 2 patients treated with curcumin (500 mg) capsules three times daily for 14 days as an adjuvant to standard triple therapy.Results: The result showed that the use of curcumin as adjuvant therapy produced highly significant improvement in healing efficacy which was significantly distinguished in duodenal ulcer patients compared to gastric ulcer groups 2 patients (p<0.05), along with a highly significant reduction in pro-inflammatory IL-1β level in group 2 patients (p<0.01). Conclusion: This study revealed that addition of curcumin as adjuvant therapy produced improvement in ulcer healing efficacy, and controlled the inflammatory and oxidative stress process induced by H. pylori infection.